{"id":18286,"date":"2021-02-27T00:49:51","date_gmt":"2021-02-26T19:19:51","guid":{"rendered":"https:\/\/functionalnutritionlab.com\/blog\/?p=1667"},"modified":"2025-08-28T14:52:17","modified_gmt":"2025-08-28T14:52:17","slug":"the-chemistry-of-coffee","status":"publish","type":"post","link":"https:\/\/www.fxnutrition.com\/blog\/the-chemistry-of-coffee","title":{"rendered":"The Chemistry of Coffee"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Although caffeine is found in over 100 plants worldwide, its effects are most potent in coffee. This potency stems from coffee\u2019s high concentration of two other stimulants<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">theophylline and theobromine. Like caffeine, these two other stimulants are classified as alkaloid compounds that naturally occur in both plants and animals.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Coffee is primarily consumed for its mood elevating and stimulating effects, which occur about 30 minutes after ingestion. Those energizing results are due to its ability to increase both dopamine and adrenaline in the central nervous system.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dopamine is a short-firing chemical, and it\u2019s stoked by pursuit and desire. That means that dopamine is the brain chemical that will take you on the <\/span><i><span style=\"font-weight: 400;\">hunt<\/span><\/i><span style=\"font-weight: 400;\">. And dopamine creates excitement and the sensation of a thrill as you embark on the chase<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">whether for your next romantic partner, the job of your dreams, a cupcake, or that afternoon cup of coffee.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adrenaline is also associated with drive and motivation. Adrenaline is one of our \u201cfight or flight,\u201d or immediate response, hormones. In an emergency, adrenaline increases your blood pressure, respiratory rate, heart rate, and general level of alertness and anxiety. It also redirects blood from your essential organs to your limbs so you can run or fight. This can disrupt the body\u2019s ability to perform normal and parasympathetic functions such as digestion, absorption, detoxification, elimination and reproduction.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The release of these two brain chemicals after a good ol\u2019 caffeine jolt helps you feel more alert and ready to tackle whatever is ahead of you in your day. But that doesn\u2019t come without a price. The increase in dopamine and adrenaline is achieved by blocking another brain chemical: adenosine. One of adenosine\u2019s natural functions is to thwart the release of dopamine, but that\u2019s not all it does&#8230;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Typically, our production of adenosine increases with each hour we are awake. The chemical is responsible for energy transfer at a cellular level (think ATP and ADP), modulating internal inflammation (which we\u2019ll come back to later), as well as coronary vasodilation. Adenosine is also an inhibitory neurotransmitter. In this way it suppresses the production of dopamine throughout the day and plays a role in promoting sleep. Coffee decreases the production of this nucleoside, affecting many biochemical processes as a result.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In short, caffeine keeps you awake and adenosine makes you sleepy. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">We\u2019re going to explore some of the challenges that coffee may pose on the body beyond the suppression of adenosine production, but please don\u2019t throw your hot morning brew at me! Truth be told, I\u2019m not one to refuse an organic decoction on occasion. And coffee has, no doubt, been associated with some positive health benefits due to its antioxidants and nutrient make-up.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That said, I do find it helpful to understand some of the <\/span><i><span style=\"font-weight: 400;\">risk and reward<\/span><\/i><span style=\"font-weight: 400;\"> of any one food. This helps us get out of the mindset of anything being a \u201cgood\u201d or \u201cbad\u201d food and brings us into the importance of bio-individuality. Plus it helps us to better explain to clients\u2014<\/span><span style=\"font-weight: 400;\">based on their healing needs, goals, and genetic and physiologic make-up\u2014<\/span><span style=\"font-weight: 400;\">why we may need to make a diet or lifestyle change to best support them.<\/span><\/p>\n<h2><b>The Downside of Drinking Coffee <\/b><b>\u2013<\/b><b> Many Branches, Just 3 Roots<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Having more energy and motivation might sound like a good thing. And perhaps it is in the short term. But how is that habitual cup of Joe actually thwarting get up and go? On a basic level, one problem is that caffeine and coffee can be addictive. Consuming just a small amount of coffee regularly (less than one cup) can lead to symptoms of withdrawal for some individuals when removed. Have you ever experienced this? I know I have! And I\u2019ve seen many clients suffering fatigue and headaches as they try to \u201cquit the coffee habit\u201d.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Beyond addictive patterning, coffee has other effects on the body worth considering:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">over-stimulation of the central nervous system (leading to increased risk of insomnia, adrenal fatigue, irritability and heart issues)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">elevated blood pressure\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">heartburn and other gastrointestinal problems\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">fibrocystic breast disease\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">dehydration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">compromised immunity\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">At the Functional Nutrition Alliance, we always look at chronic health issues through a \u201c3 Roots, Many Branches\u201d lens. Those three roots are the genes (or genetic predisposition), digestion, and inflammation. That\u2019s why we\u2019re going to view coffee through the perspective of these three roots, though as you can see above, there are many branches (i.e., signs and symptoms) that can be linked to coffee consumption.\u00a0\u00a0<\/span><\/p>\n<h3><b>Caffeine Genes<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">For some of your clients, and maybe even you, coffee is never the best fuel for the day. In fact, for those that cannot process caffeine well, even the smallest amount will result in feelings of anxiety, jitters, and a sleepless night. And these individuals usually know it! Coffee, green tea, or even hot cocoa will be a big \u201cno, thank you\u201d for these people.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Caffeine metabolism has been found to be linked to two genes and their variants<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">the CYP1A2 gene which produces a liver enzyme that breaks down caffeine and the AHR gene which can determine how much of that enzyme your body makes. <\/span><\/p>\n<h3><b>Coffee\u2019s Effect on the Gut<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Interestingly, the study of effects of coffee on the gastrointestinal system have dated back to the end of the 9th century, where it was linked to the onset of certain digestive disorders. The overwhelming research on the subject reveals two things:\u00a0<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">smaller amounts of coffee are not destructive to the digestive systems of <\/span><i><span style=\"font-weight: 400;\">some<\/span><\/i><span style=\"font-weight: 400;\"> individuals, and\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">for those that are intolerant to the effects of coffee because of their physiology (or genes), even small amounts can, overtime, be harmful<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">There is further conflict and controversy around whether and to what extent coffee consumption takes a toll on the esophageal sphincter, stomach acid and intestinal permeability. Yet one thing that\u2019s not questioned is coffee\u2019s role as a laxative. It acts as a laxative by causing the gastrointestinal muscles to contract.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It should also be noted that, like sugar, coffee can also rob the body of essential nutrients. These include calcium and the essential B vitamins that support our brain and detoxification health.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Finally, the auxiliary digestive organ, the liver, plays the most prominent role in the metabolism of caffeine. Coffee consumption increases liver activity and can place additional stress on this already taxed and hard-working powerhouse. In addition to caffeine, coffee can contain a wide constellation of toxic chemicals, depending on where it originates and how it was processed, that can add insult to liver injury.\u00a0<\/span><\/p>\n<h3><b>How Caffeine Compromises Immunity<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Research suggests that, along with psychoactive effects, caffeine impacts the innate functioning of our endocrine, cardiovascular, respiratory, renal and gastrointestinal systems. More recently, studies are also weighing the impact of caffeine on the immune system.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Remember how I mentioned that adenosine has a role in modulating inflammation? Well it also has a part in signal transduction, the cellular process by which a molecule outside the cell signals a molecule on the cell surface to alter the environment within the cell. One of these signal transductions is cyclic adenosine monophosphate or cAMP. cAMP is a potent immunomodulator, suppressing inflammation and potentially wreaking havoc within the body.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As caffeine antagonizes the adenosine receptors, it suppresses the expression of the immune cells and can promote systemic inflammation. This occurs even while providing a short-term energy boost.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition, energy fueled by adrenaline could, over time, damage the immune system. The adrenal glands, which produce adrenaline, are at the pulse of the body\u2019s hormonal stress response. These glands produce both adrenaline and cortisol, your two major fight-or-flight hormones. And that stress response, when repeatedly triggered, is a main precursor to an overactive immune system<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">a system that attacks itself<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">as seen in autoimmune conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The constant stress on the adrenal glands and the continual release of the fight-or-flight hormones prompted by habitual caffeine consumption are one cause for the body to lose its immune tolerance. You\u2019re not the only one who gets eager and enthusiastic. Your immune system gets hyper, too!\u00a0<\/span><\/p>\n<h2><b>Helping Clients Kick the Habit<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">When addressing the three roots (genes, digestion and inflammation), we always aim to <\/span><i><span style=\"font-weight: 400;\">clear<\/span><\/i><span style=\"font-weight: 400;\"> the diet, lifestyle and body of any potentially inflammatory agents. We also look to <\/span><i><span style=\"font-weight: 400;\">calm<\/span><\/i><span style=\"font-weight: 400;\"> the entire system. This means it might be time for a coffee \u201cdetox.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have clients who are working to cut back on caffeine or need to eliminate coffee as part of your upstream exploration of their health issues, here\u2019s a <\/span><span style=\"font-weight: 400;\">free download<\/span><span style=\"font-weight: 400;\"> with tips on removing it from their morning routine. I hope you\u2019ll find this guide helpful in your practice!<\/span><\/p>\n<p><a href=\"https:\/\/fxna.s3-us-west-2.amazonaws.com\/misc\/pdf\/FxNA-caffeine-kick-it.pdf\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"aligncenter wp-image-1670\" src=\"\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band.jpg\" alt=\"\" width=\"623\" height=\"357\" srcset=\"https:\/\/www.fxnutrition.com\/blog\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band.jpg 1920w, https:\/\/www.fxnutrition.com\/blog\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band-300x172.jpg 300w, https:\/\/www.fxnutrition.com\/blog\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band-1024x587.jpg 1024w, https:\/\/www.fxnutrition.com\/blog\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band-768x440.jpg 768w, https:\/\/www.fxnutrition.com\/blog\/wp-content\/uploads\/2021\/02\/free-download-kick-caffeine-band-1536x880.jpg 1536w\" sizes=\"(max-width: 623px) 100vw, 623px\" \/><\/a><\/p>\n<hr \/>\n<h5><i><span style=\"font-weight: 400;\">References:<\/span><\/i><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Institute of Medicine (US) Committee on Military Nutrition Research. <\/span><\/i><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK223802\/\"><i><span style=\"font-weight: 400;\">Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations.<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> Washington (DC): National Academies Press (US); 2001. 2, Pharmacology of Caffeine. Available from: <\/span><\/i><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK223808\/\"><i><span style=\"font-weight: 400;\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK223808\/<\/span><\/i><\/a><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Marcello Solinas, Sergi Ferr\u00e9, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli and Steven R. Goldberg. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.22-15-06321.2002\"><i><span style=\"font-weight: 400;\">Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens.<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: <\/span><\/i><a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.22-15-06321.2002\"><i><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1523\/JNEUROSCI.22-15-06321.2002<\/span><\/i><\/a><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Yang, A., Palmer, A. A., &amp; de Wit, H. (2010). <\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s00213-010-1900-1\"><i><span style=\"font-weight: 400;\">Genetics of caffeine consumption and responses to caffeine.<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> Psychopharmacology, 211(3), 245\u2013257. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s00213-010-1900-1\"><i><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1007\/s00213-010-1900-1<\/span><\/i><\/a><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Boekema, P. J., Samsom, M., van Berge Henegouwen, G. P., &amp; Smout, A. J. (1999). <\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/003655299750025525\"><i><span style=\"font-weight: 400;\">Coffee and gastrointestinal function: facts and fiction.<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> A review. Scandinavian journal of gastroenterology. Supplement, 230, 35\u201339. https:\/\/doi.org\/10.1080\/003655299750025525<\/span><\/i><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Ribeiro, J. A., &amp; Sebasti\u00e3o, A. M. (2010). <\/span><\/i><a href=\"https:\/\/doi.org\/10.3233\/JAD-2010-1379\"><i><span style=\"font-weight: 400;\">Caffeine and adenosine.<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> Journal of Alzheimer&#8217;s disease : JAD, 20 Suppl 1, S3\u2013S15. https:\/\/doi.org\/10.3233\/JAD-2010-1379<\/span><\/i><\/h5>\n<h5><i><span style=\"font-weight: 400;\">Muqaku, B., Tahir, A., Klepeisz, P., Bileck, A., Kreutz, D., Mayer, R. L., Meier, S. M., Gerner, M., Schmetterer, K., &amp; Gerner, C. (2016). <\/span><\/i><i><span style=\"font-weight: 400;\">Coffee consumption modulates inflammatory processes in an individual fashion.<\/span><\/i><i><span style=\"font-weight: 400;\"> Molecular nutrition &amp; food research, 60(12), 2529\u20132541. <\/span><\/i><i><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1002\/mnfr.201600328<\/span><\/i><\/h5>\n<hr \/>\n<h2><span style=\"font-weight: 400;\">Related Blogs:<\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.fxnutrition.com\/articles\/oh-the-fumes\/\" target=\"_blank\" rel=\"noopener\">Detoxification &amp; Anxiety: a Web of Interconnections<\/a><br \/>\n<a href=\"https:\/\/www.fxnutrition.com\/articles\/epigenetics\/\" target=\"_blank\" rel=\"noopener\">Epigenetics<\/a><br \/>\n<a href=\"https:\/\/www.fxnutrition.com\/articles\/multifactorial\/\" target=\"_blank\" rel=\"noopener\">Multifactorial<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although caffeine is found in over 100 plants worldwide, its effects are most potent in coffee. This potency stems from coffee\u2019s high concentration of two other stimulants\u2013theophylline and theobromine. Like caffeine, these two other stimulants are classified as alkaloid compounds that naturally occur in both plants and animals.\u00a0 Coffee is primarily consumed for its mood [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18181,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[133],"tags":[171,167],"class_list":["post-18286","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diet-lifestyle-support","tag-hormone-health","tag-nutrition"],"_yoast_wpseo_sitemap-include":null,"_yoast_wpseo_canonical":null,"_yoast_wpseo_redirect":null,"_yoast_wpseo_opengraph-description":null,"_yoast_wpseo_opengraph-title":null,"_yoast_wpseo_focuskeywords":"[]","_yoast_wpseo_meta-robots-noindex":null,"_yoast_wpseo_meta-robots-nofollow":null,"_yoast_wpseo_title":"The Chemistry of Coffee - Functional Nutrition Alliance","_yoast_wpseo_metadesc":"Discover the complexities of coffee and its effects on the body. Learn how caffeine interacts with our brain chemistry and the potential risks associated with coffee consumption, along with insights for holistic nutrition and functional health practices.","_yoast_wpseo_focuskw":"Caffeine and Coffee","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.6 (Yoast SEO v25.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Chemistry of Coffee - Functional Nutrition Alliance<\/title>\n<meta name=\"description\" content=\"Discover the complexities of coffee and its effects on the body. 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